4ounce tube of Desitin Daily Defense Diaper Rash Cream works from the first use to help soothe treat and prevent diaper rash From the 1 choice for diaper rash relief by Pediatricians and parents this infant diaper cream instantly forms a protective layer on your babys skin for diaper rash relief and prevention Made with zinc oxide its fastacting hypoallergenic formula helps seal out wetness to treat diaper rash from the first signs and is clinically shown to provide diaper rash relief This diaper cream is specially formulated for babies tender skin and is paraben phthalate and dyefree so its gentle enough to use at every diaper change